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Setting expectations appropriately based on individual circumstances helps maintain adherence through the time needed for full benefit

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The intracellular domain has three portions: a juxtamembrane sequence that downregulates kinase activity which is followed by phosphorylation of Ser975 which is a catalytic region that promotes kinase activity leading to transphosphorylation of Tyr1234 and Tyr1235

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The latest generation of Pico lasers can markedly improve melasma within a few treatment sessions, whilst novel chemical peels can quickly, effectively & safely remove melasma pigment in most patients